Marine Endophytic Fungi and the Production of Bioactive Compounds with Antimicrobial Properties
Mohamed H. Yassin Ahmed A. Hamed, Mervat G. Hassan, Mohamed E. Elawady, Dina.M.M. Elnagar
Marine sponges, renowned for their exceptional biodiversity, serve as natural reservoirs for a wide array of microorganisms, particularly endophytic fungi, which have demonstrated a propensity for synthesizing bioactive compounds with remarkable potential in the realms of antimicrobial and anticancer therapeutics. In the current investigation, marine sponges were meticulously procured from two distinct locales in the coastal waters of Hurghada, Egypt, and their internal tissues were harnessed as a source of endophytic fungi.
Isolation techniques were employed to extract and cultivate these endophytic fungi from the sponge tissues. Subsequently, the isolated fungal strains underwent a rigorous screening process to assess their proficiency in generating bioactive compounds possessing potent antimicrobial properties. The evaluation encompassed the efficacy of these compounds against a panel of four pathogenic microorganisms: Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger.