Bacteria translocation related to disease severity pre and post treatment hepatitis C virus.
Sabah A. AboElmaatyAya M. Abd-allah, Khaled A. El-Dougdoug
Hepatitis C virus (HCV) infection is complicated by microbial translocation throughout the movement of living bacteria or their endotoxins from the intestinal lumen to the mesenteric lymph nodes and other extra-intestinal locations. The present study aimed to evaluate bacterial translocation in patients with HCV infection pre and post-treatment. Results showed that HCV titer was high in pretreated patients and low in post-treated patients, the isolated bacteria were identified according to morphological cultures, the VITEK-2-system, and antibiotics. It was found that 76% of pretreated patients gave bacterial isolates and divided them according to symptoms; 16% showed mild symptoms, 49.33% showed moderate symptoms and 10.66% showed severe symptoms. The isolated bacteria were mostly multi-drug resistant. The frequency percent of trans-located bacteria was 29.33% for Gram-positive cocci bacteria included (25.33% Streptococcus spp and 4% Staphylococcus spp), and 46.66% for Gram-negative bacilli bacteria included (33.33% E.Coli and 13.33% Klebsiella spp). 6.66% of post-treated patients gave bacterial growth as 2.66% showed moderate symptoms, and 4% showed severe symptoms. The percent of bacteria was 5.33% for Gram-positive cocci bacteria included (4% Staphylococcus spp and 1.33% Streptococcus spp), and 1.33% for Gram-negative bacilli bacteria. According to the studied patients, Results showed a significant difference between pre and post-treated patients as the highest percentage of bacterial growth was found in the pretreated patients and more bacterial isolates were from patients with severe symptoms while most samples that gave no growth were from patients who showed mild symptoms