Journal of Basic and Environmental Sciences

Abstract of:

The prognostic value of P53 and CA15.3 tumor markers in breast cancer patient

Noha B.E Tohamy ,Nassr Allah Abd El-Hameid, Reem El Shenawy, Loay Kassem, Mohamed N. Seddek

Breast cancer is the second most prevalent malignancy among women. The cancer antigen CA 15-3 has been used as a putative serum marker of occult and recurring breast carcinoma .The p53 gene is mutated in human cancer. Immunohistochemistry reveals that the mutant p53 protein is more stable and has a longer half-life compared to the wild type. This study aims to estimate the role of the p53 protein in diagnosing and confirming breast cancer compared to cancer antigen 15-3 (CA15-3.The current research involved 68 women diagnosed with breast cancer who were aged 30-60 years old. The control group consisted of 10 healthy women. Before surgery, sera samples were collected. The Sandwich-ELISA technique measures the amount of p53 protein in sera. An immunoradiometric assay (IRMA) kit was used to measure the sera CA 15-3 levels. The study found a higher level of CA15-3 In breast cancer patients (186.7±218) compared to healthy control groups (8.88±3.7). There are no significant associations between p53 protein levels and patient clinical features such as age and grade. Furthermore, the p53 protein value did not correlate with serum CA 15-3.

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Journal of Basic and Environmental Sciences

J. Bas. Environ.Sci.

Abstract of:

The prognostic value of P53 and CA15.3 tumor markers in breast cancer patient