Effect of Moringa oleifera on some physiological parameters in diclofenac treated rats
Maha, G. Mohamed ,Eman, M. S. Shaheen; Marwa, A. E. Abd-El Maksoud and Mohamed N. Seddek
The present work aims to study the potential effect of aqueous leaves extract Moringa oleifera (MO) on male albino rats treated orally with diclofenac sodium (DcNa). Forty-five male albino rats were used and randomly divided into 5 groups as follows: group I “normal group”, group II “DcNa group”, group III “MO group”, group IV “DcNa then MO group” and group V “MO then DcNa group”. Treatment with DcNa showed a significant decrease in body weight while caused significant increases in relative organs weight (liver, kidney, spleen and brain). Moringa oleifera caused a significant increase in body weight while showed non-significant decreases in relative organs weight (liver, kidney and spleen). DcNa exhibited significant decreases in WBCs count, lymphocytes % and neutrophil % while caused a significant increase in monocyte %. Also, there were non-significant increase and decrease in eosinophil % and basophil % respectively. Treatment with MO showed non-significant increases in white blood cell count, monocyte % and neutrophil % while showed non-significant decrease in lymphocyte %. Eosinophil % and basophil % were increased significantly. Administration of DcNa caused significant decreases in serum total protein, albumin and globulin levels. Treatment with Moringa oleifera showed a significant increase in serum albumin level while showed non-significant increases in serum total protein and globulin levels.
The present study suggests that Moringa oleifera is useful in maintaining the harmful effect of diclofenac sodium in male albino rats.