Potentiometric determination of alfuzosin hydrochloride in pharmaceutical preparations and biological fluids using modified carbon paste electrodes
Alaa A.A.M. Hasseb Gehad G. Mohamed, Sally E.A. Elashery
The performance characteristic of sensitive modified carbon paste electrodes (MCPE) was suggested for alfuzosin hydrochloride (ALFHC) determination in its pure, pharmaceutical preparations and biological samples. Various experimental conditions namely materials types that used to prepare the working electrodes (plasticizer), pH, titrant, interfering ions and life time were studied. MCPE gave suitable response to ALFHC over pH range 2.9 – 6.7 for electrode (I) and 2.9-7.7 for electrode (II). ALFHC selectivity relative to different potential interfering species was reported. The MCPEs were used over a period of 3 months with a good reproducibility. The studied sensors were successfully applied to determine ALFHC in its pharmaceutical preparations and biological fluid samples. The obtained results are compared with the official method.