Transition Metal Complexes of Biologically Active Ligands; Preparation, Characterization and Biological Evaluation
Moustafa E. MoustafaHelmy E. Megahed and Doaa S. Yousef
The mixed ligands complexes formed between the biologically active ligands; N-Acetylcysteine (NAC) and 2- Acetylthiophene (AcTH) (secondary ligands), levofloxacin (Levo) (primary ligand) and Mn2+, Fe3+, Ni2+, Co2+ and Cu2+ were prepared and their chemical structures were studied and characterized by elemental analysis, molar conductivity, FT-IR, UV-Vis spectroscopy, magnetic moments, and thermogravimetric (TG&DTA) analysis. Spectral and elemental analysis data showed that both levofloxacin drug acts as monovalent bidentate coordinating to the metal ion via OO fashion while the secondary ligands act as neutral bidentate coordinating through OS fashion with octahedral geometry in all cases. The antimicrobial activity of the mixed ligand complexes has been studied by screening against some gram positive and gram-negative bacteria, where it was found that they have enhanced activity. The antitumor activities of some selected complexes were tested against HEPG2 cell line and compared to that of Vinblastine as a standard drug.