Journal of Basic and Environmental Sciences

Vol.6 No.2


Effect of Vascular Disrupting Agent (CA-4DP) and Ionizing Radiation on Tumor Growth in Rats
Z. M. AlghzzawyT. K. Elmaghraby, S. A. Hagag, M. H. Awwad

Abstract:

Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide. This study was performed to explore the effect of low dose γ-irradiation (LDR) and Combretastatin A-4 disodium phosphate (CA-4DP) on HCC induced by N-nitrosodiethylamine (NDEA) in rats. Male Wistar albino rats were orally administrated NDEA for 17 weeks. Rats bearing HCC were intravenously injected with 10 mg/kg of CA-4DP and/or exposed to 0.20 Gy of γ-irradiation. Histopathological examination of the liver tissues was performed following 6, 24, and 48 h post CA-4DP injection. Treatment with LDR and CA-4DP resulted in extensive bleeding and necrosis in tumor tissue that was associated with HCC regression. The presented study demonstrated the promising therapeutic advantage of LDR along with CA-4DP in HCC.


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