Journal of Basic and Environmental Sciences

Abstract of:


Chemical and Bioactivity Studies on Salvia Africana-Lutea: Cytotoxicity and Apoptosis Induction by Abietane Diterpenes Isolated from Salvia Africana-Lutea


M.M.H.Arief      ,Ahmed Abde Fattah. Hussein, Abdelhamid. Mohammed, Hassan.M. ElMwafy
Re-investigation of the phytochemical constituents of Salvia africana-lutea L. methanolc extract, led to the purification and identification of six abietane diterpene (7-methoxyrosmanol (1), rosmadial (2), rosmanol (3), carnosol (4), epiisorosmanol (5), epirosmanol (6)) and rosmarinic acid methyl ester (7). The compounds 1 and 3-5 showed significant anti-proliferative effect on HT-29 and MCF-7 cells, additionally, 7-methoxyrosmanal (1) found to induce apoptosis in colorectal adenocarcinoma cells. The apoptotic pathway is characterized by the activation of caspases cascade (viz caspase 9) which climaxed in caspase-3 activation.


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