Effect of Vascular Disrupting Agent (CA-4DP) and Ionizing Radiation on Tumor Growth in Rats
Z. M. Alghzzawy ,T. K. Elmaghraby, S. A. Hagag, M. H. Awwad
Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide. This study was performed to explore the effect of low dose γ-irradiation (LDR) and Combretastatin A-4 disodium phosphate (CA-4DP) on HCC induced by N-nitrosodiethylamine (NDEA) in rats.
Male Wistar albino rats were orally administrated NDEA for 17 weeks. Rats bearing HCC were intravenously injected with 10 mg/kg of CA-4DP and/or exposed to 0.20 Gy of γ-irradiation. Histopathological examination of the liver tissues was performed following 6, 24, and 48 h post CA-4DP injection.
Treatment with LDR and CA-4DP resulted in extensive bleeding and necrosis in tumor tissue that was associated with HCC regression. The presented study demonstrated the promising therapeutic advantage of LDR along with CA-4DP in HCC.